ORCHARD PARK, N.Y. -- LeSean McCoy scored twice, including a career-best 75-yard run, and the Buffalo Bills won their second in a row by beating the Jacksonville Jaguars 28-21 on Sunday.Tyrod Taylors 16-yard touchdown pass to Justin Hunter with 10:46 remaining put the Bills ahead for good during a second half in which the teams traded the lead five times. Taylor also scored on a 7-yard run in helping to keep Buffalo in the playoff hunt.The Bills (6-5) won for the second straight week when trailing at halftime after doing so just once last season.Buffalo trailed the Jaguars 7-6 after two quarters on Sunday, and overcame a two-point deficit in a 16-12 win at Cincinnati last week.Taylor also produced just the second fourth-quarter comeback of his career, and improved to 2-11 when the Bills trail by four or more at any point in a game.The Jaguars (2-9) lost for the sixth straight game -- their longest skid since opening the 2014 season at 0-6.The game was decided with four minutes left, when the Jaguars were unable to convert a fourth-and-9 at the Buffalo 46. Blake Bortles hit Marquise Lee on a crossing pattern over the middle, but he was limited to a 4-yard gain.The Bills then took over and ran out the clock.Bortles went 13 of 26 for 126 yards and two touchdowns, and also had a career-best 81 yards rushing.The Jaguars offense was hampered by injuries. Chris Ivory, who opened the scoring with a 2-yard run, was sidelined in the first half by a hamstring injury. And then Jacksonville lost receiver Allen Hurns, also with a hamstring injury while diving into the end zone on a 12-yard catch and run .Hurns touchdown put the Jaguars up 21-20 in the opening seconds of the fourth quarter.The Bills responded with Taylor leading an eight-play, 76-yard drive which he capped with a perfectly placed pass to Hunter at the goal line. McCoy then dived across the goal line for the 2-point conversion.McCoy finished with 103 yards rushing and showed few signs of being bothered a week after having surgery for a dislocated left thumb.His two touchdowns came 33 seconds apart spanning halftime.After scoring on a 7-yard run late in the second quarter, he opened the third quarter by scoring on Buffalos first snap from scrimmage. Taking the handoff, McCoy burst off right tackle and blew past defensive backs Jalen Ramsey and Tashuan Gipson.JAGS BIG OPENINGThe Jaguars snapped the NFLs longest active drought by scoring on their opening possession for the first time in 25 games. The streak began in Week 3 of the 2015 season, and featured the Jaguars combining for three field goals, punting 18 times and turning the ball over three times.Ivorys touchdown capped an 11-play, 75-yard drive spanning 6:45. The Jaguars converted three third-down chances, including their last one courtesy of a defensive holding penalty against Corey White on third-and-goal from the 3.WELCOME BACKSammy Watkins had three catches for 80 yards -- including a 62-yard catch -- in playing his first game in nine weeks since aggravating an injury to his surgically repaired left foot.INJURIESJaguars: Ivory (hamstring), WR Rashad Greene Sr. (Achilles) and FS Peyton Thompson (ankle) and Hurns (hamstring) did not return. Hurns was hurt while diving into the end zone on his touchdown catch.Bills: CB Ronald Darby (concussion), WR Walter Powell (left ankle).NEXT UPJaguars: Host Denver on Dec. 4.Bills: At Oakland on Dec. 4.---For more NFL coverage:AP NFL website: www.pro32.ap.org and www.twitter.com/AP-NFL Christian Laettner Pistons Jersey . Pirlo limped out of Sundays 1-0 win over Udinese after just 13 minutes. Juventus says Pirlo underwent tests on Monday which revealed he has "a second-degree lesion to the collateral medial ligament in his right knee. Tony Snell Jersey . Irving scored 23 points, Tristan Thompson had 20 points and 10 rebounds and the Cavaliers beat the Denver Nuggets 117-109 on Friday night. https://www.pistonsrookiesshop.com/Christian-Wood-City-Edition-Jersey/ . Mickelson barely made the cut but had the best round of the day with nine birdies and an eagle coupled with two bogeys to sit two shots behind leader Craig Lee of Scotland. Lee shot a 69 for a 12-under 204 total. "I just love the fact I am in contention and have an opportunity in my first tournament of the year here in Abu Dhabi," Mickelson said. Jose Calderon Pistons Jersey .ca. Kerry, Just watched the shootout in the Coyotes/Leafs game and I have to ask, why was the James van Riemsdyk goal allowed to count? All of the video replays we were shown on TV were inconclusive about whether the puck had entirely crossed the line or not. Langston Galloway Pistons Jersey . Numbers Game examines the deal that sees Michael Del Zotto and Kevin Klein switch places. The Predators Get: D Michael Del Zotto. Mike Greenberg, Booger McFarland and Mike Golic Jr. will welcome LSU coach Les Miles (8 a.m. ET), Tennessee coach Butch Jones (9:00) and Georgia coach Kirby Smart (9:30) to the show on Monday.Get in touch with Mike & Mike by emailing (mikeandmike@espnradio.com) or tweeting (@MikeAndMike) the guys -- we will be with you from 6-10 a.ddddddddddddm. ET. Follow all of the action on ESPN2, ESPN Radio and ESPNRadio.com. ' ' '